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KMID : 0380620220540040398
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 4 p.398 ~ p.402
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Effects of black chokeberry on cholesterol metabolism in HepG2 cells
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Lee Sang-Gil
Kim Boh-Kyung
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Abstract
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Black chokeberry (Aronia melanocarpa), a rich source of polyphenols, exerts hypocholesterolemic effects. However, little is known about its effects on the regulation of the hepatic cholesterol metabolism and the underlying mechanisms. In the present study, the effects of polyphenol-rich black chokeberry extract (CBE) on hepatic cholesterol metabolism were investigated by measuring the expression of genes involved in the absorption, de novo synthesis, and efflux of cholesterol in HepG2 cells. There was a significant reduction in the expression levels of genes involved in cholesterol metabolism, the low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and sterol regulatory element-binding protein 2, in CBE-treated HepG2 cells. Meanwhile, CBE increased the expression levels of genes involved in cholesterol and bile acid efflux. The expression levels of mitochondrial fatty acid oxidation genes increased, whereas those of lipogenic genes decreased following CBE treatment. These data suggest that the consumption of black chokeberry may be beneficial for the prevention of hypercholesterolemia.
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KEYWORD
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black chokeberry, Aronia melanocarpa, choelsterol metabolism, hypocholesterolemia, HepG2 cells
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